GDP metabolic process

Across TCGA cell cohorts, RNA activity of the GDP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP2, EPS8L2, and HDHD3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GDP metabolic process activity versus TJP2 in BLOOD_Lymphoma (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TJP2 →	+2.151	+1.064	.003	.002	2	8
BONE	EPS8L2 →	+2.966	+1.600	.008	<.001	3	5
LUNG_NSCLC_LUAD	HDHD3 →	+1.151	+1.132	.002	<.001	3	5
LUNG_NSCLC_LUAD	DLG3 →	+1.348	+1.121	.001	<.001	3	4
LUNG_NSCLC_LUAD	SH3BP2 →	+1.416	+0.921	.002	.004	3	4
BONE	H3C10 →	+1.198	+1.410	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046710 vs TJP2 — BLOOD_Lymphoma

Explore this scatter interactively →