Decidualization

Across TCGA patient cohorts, RNA activity of the Decidualization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, ENO2, and COLGALT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Decidualization activity versus SPP1 in UCEC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPP1 →	+2.208	+0.659	<.001	<.001	3	8
PDAC	ENO2 →	+1.072	+0.437	<.001	<.001	3	7
LSCC	COLGALT1 →	+0.463	+0.597	<.001	.001	3	6
GBM	EDIL3 →	+1.311	+0.269	<.001	.002	3	6
PDAC	LINC01705 →	+0.900	+0.306	.008	.003	3	6
BRCA	PLOD1 →	+0.517	+0.664	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046697 vs SPP1 — UCEC

Explore this scatter interactively →