Decidualization

Across TCGA cell cohorts, RNA activity of the Decidualization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA5, TINF2, and VASP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GOLGA5 grouped by Decidualization-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GOLGA5 →	-0.726	-1.202	<.001	<.001	3	4
OVARY	TINF2 →	-0.558	-1.180	.005	.001	3	4
CNS	VASP →	-1.423	-1.127	<.001	.005	3	4
CNS	SLC9A1 →	-0.628	-0.696	.001	.008	3	4
PANCREAS	KDM4D →	+0.445	+1.109	.001	.001	3	3
SKIN	DAD1 →	-0.329	-0.876	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GOLGA5 by Decidualization activity — CNS

Explore this box plot interactively →