Decidualization

Across TCGA cell cohorts, RNA activity of the Decidualization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP1, YY1AP1, and NUP133, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Decidualization activity versus PARP1 in OVARY (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PARP1 →	+1.042	+0.150	<.001	<.001	3	6
LIVER	YY1AP1 →	+0.699	+0.128	<.001	<.001	3	5
OVARY	NUP133 →	+0.581	+0.115	.001	<.001	3	5
BONE	MED30 →	+0.833	+0.068	.009	.009	2	6
BREAST	EXOSC10 →	+0.587	+0.118	.006	.004	2	6
BLOOD_Lymphoma	TRMT1L →	+0.473	+0.088	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046697 vs PARP1 — OVARY

Explore this scatter interactively →