Response to mercury ion

Across TCGA patient cohorts, RNA activity of the Response to mercury ion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HEATR1, PDCD11, and RANGAP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mercury ion activity versus HEATR1 in LSCC (Pearson r = -0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HEATR1 →	-0.357	-0.094	<.001	<.001	3	9
LSCC	PDCD11 →	-0.328	-0.078	<.001	<.001	3	9
BRCA	RANGAP1 →	-0.220	-0.069	<.001	<.001	3	9
OV	USP39_S46 →	-1.027	-0.064	<.001	<.001	3	8
BRCA	UTP4 →	-0.417	-0.097	<.001	<.001	3	8
LSCC	ESF1_S663 →	-0.759	-0.113	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046689 vs HEATR1 — LSCC

Explore this scatter interactively →