Response to mercury ion

Across TCGA patient cohorts, RNA activity of the Response to mercury ion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAOA, SRSF5, and ARHGAP26-IT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mercury ion activity versus MAOA in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAOA →	+1.115	+0.105	<.001	.001	3	4
COAD	SRSF5 →	+0.282	+0.092	.001	.003	3	4
COAD	ARHGAP26-IT1 →	+0.206	+0.075	.002	.003	3	4
LSCC	KLRB1 →	-0.423	-0.071	.003	.001	3	3
GBM	ALAD →	+0.403	+0.117	<.001	.004	3	3
GBM	HBA2 →	+1.338	+0.105	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046689 vs MAOA — BRCA

Explore this scatter interactively →