Response to copper ion

Across TCGA cell cohorts, RNA activity of the Response to copper ion pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CKAP4, ASCC2, and CHCHD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CKAP4 grouped by Response to copper ion-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CKAP4 →	+1.052	+0.151	.004	.004	3	4
BLOOD_Lymphoma	ASCC2 →	+0.707	+0.229	.004	<.001	3	4
URINARY_TRACT	CHCHD5 →	-0.864	-0.243	.003	.009	2	5
LUNG_NSCLC_LUAD	MINDY4 →	-0.595	-0.145	.003	.008	2	5
PANCREAS	TRIM29 →	-3.129	-0.185	.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	SHPRH →	-0.839	-0.230	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CKAP4 by Response to copper ion activity — SKIN

Explore this box plot interactively →