Response to copper ion

Across TCGA cell cohorts, RNA activity of the Response to copper ion pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AADAT, ATG9B, and RXFP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AADAT grouped by Response to copper ion-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AADAT →	-0.225	-0.168	<.001	<.001	3	5
BREAST	ATG9B →	-0.194	-0.152	<.001	<.001	3	5
URINARY_TRACT	RXFP4 →	-0.153	-0.175	.001	.001	3	4
URINARY_TRACT	ATP5MF →	+0.351	+0.175	.007	.001	3	4
LUNG_SCLC	LRRC15 →	-0.242	-0.145	<.001	<.001	3	4
CNS	CNR1 →	-0.207	-0.081	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AADAT by Response to copper ion activity — LARGE_INTESTINE

Explore this box plot interactively →