Response to organophosphorus

Across TCGA patient cohorts, RNA activity of the Response to organophosphorus pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D22B, PSMB8, and OAS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to organophosphorus activity versus TBC1D22B in PDAC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TBC1D22B →	-0.268	-0.500	.002	<.001	3	4
LUAD	PSMB8 →	-0.412	-0.284	.007	.002	2	5
LUAD	OAS3 →	-0.938	-0.330	<.001	.007	3	4
UCEC	BZW2 →	-0.525	-0.129	.001	.006	3	4
OV	ECM2 →	+1.087	+0.361	<.001	<.001	3	4
LUAD	TAP1 →	-0.466	-0.277	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046683 vs TBC1D22B — PDAC

Explore this scatter interactively →