Response to organophosphorus

Across TCGA cell cohorts, RNA activity of the Response to organophosphorus pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL22, DNAAF2, and SH3KBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL22 grouped by Response to organophosphorus-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RPL22 →	-0.877	-0.177	<.001	.004	3	4
OESOPHAGUS	DNAAF2 →	-0.932	-0.195	.001	.001	3	4
LIVER	SH3KBP1 →	+1.810	+0.285	.004	.002	3	3
UPPER_AERODIGESTIVE_TRACT	TLN2 →	-1.908	-0.280	.001	.001	3	3
PANCREAS	TRPM2 →	-2.019	-0.090	<.001	.009	3	3
BLOOD_Myeloma	TAF10 →	+0.731	+0.326	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL22 by Response to organophosphorus activity — OESOPHAGUS

Explore this box plot interactively →