Response to antibiotic

Across TCGA patient cohorts, RNA activity of the Response to antibiotic pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH1, TGFB3, and SSPN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to antibiotic activity versus MYH1 in LSCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MYH1 →	-0.305	-0.195	.002	<.001	3	4
LSCC	TGFB3 →	-0.712	-0.136	.002	.009	3	4
LSCC	SSPN →	-0.604	-0.138	.002	.007	3	4
LSCC	MYH8 →	-0.276	-0.149	.004	.007	3	4
LSCC	GLIPR1 →	-0.354	-0.120	.002	.007	3	4
LSCC	CDH11 →	-0.673	-0.152	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046677 vs MYH1 — LSCC

Explore this scatter interactively →