Response to antibiotic

Across TCGA patient cohorts, RNA activity of the Response to antibiotic pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC5, SNTB2_S129, and YY1AP1_S724, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to antibiotic activity versus RFC5 in LSCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC5 →	+0.382	+0.187	<.001	<.001	3	3
LSCC	SNTB2_S129 →	-0.704	-0.210	<.001	<.001	3	3
BRCA	YY1AP1_S724 →	+0.491	+0.307	.001	.009	3	3
UCEC	CAVIN3_S56 →	-0.766	-0.363	.003	.004	2	4
LUAD	AHNAK_S5332 →	-0.543	-0.185	.001	<.001	3	3
LUAD	FLNA_T2336 →	-0.859	-0.253	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046677 vs RFC5 — LSCC

Explore this scatter interactively →