Retinal cell programmed cell death

pathway activity — cross-omics
GO:0046666Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Retinal cell programmed cell death pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS3, ZEB1, and BCL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADRBMS3 →+0.602+0.118<.001<.00136
OVZEB1 →+1.075+0.158.008.00536
BRCABCL2 →+1.441+0.171<.001<.00135
LUADCEP55 →-1.138-0.090<.001<.00135
LUADSGCA →+0.988+0.085<.001<.00135
OVFHL5 →+0.951+0.163.001.00235
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration