Male sex differentiation

Across TCGA patient cohorts, RNA activity of the Male sex differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZZEF1, GTF3C2, and MSH2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male sex differentiation activity versus ZZEF1 in CCRCC (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZZEF1 →	-0.153	-0.027	<.001	<.001	3	6
HNSC	GTF3C2 →	+0.206	+0.045	<.001	<.001	3	6
LSCC	MSH2 →	+0.423	+0.026	<.001	.001	3	6
BRCA	FSTL1 →	+0.364	+0.013	.001	.007	3	6
OV	LARP6_S56 →	+0.765	+0.034	<.001	.001	3	5
CCRCC	CD2 →	-0.506	-0.019	<.001	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046661 vs ZZEF1 — CCRCC

Explore this scatter interactively →