Male sex differentiation

Across TCGA patient cohorts, RNA activity of the Male sex differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2L2, TRPC1, and TAGLN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male sex differentiation activity versus BCL2L2 in COAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BCL2L2 →	+0.340	+0.410	.009	.006	3	3
OV	TRPC1 →	+0.627	+0.530	.007	.003	3	3
COAD	TAGLN →	+1.073	+0.489	<.001	.003	3	3
OV	LRRC17 →	+0.716	+0.564	.007	.002	3	3
CCRCC	DOCK1 →	+0.298	+0.444	.004	.003	3	3
CCRCC	JAM3 →	+0.555	+0.400	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046661 vs BCL2L2 — COAD

Explore this scatter interactively →