Male sex differentiation

Across TCGA cell cohorts, RNA activity of the Male sex differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBX1, GKAP1, and TP53BP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PBX1 grouped by Male sex differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PBX1 →	-1.470	-0.945	.006	.004	3	4
LARGE_INTESTINE	GKAP1 →	-0.654	-0.609	.005	.006	3	4
BREAST	TP53BP2 →	-0.755	-0.323	.002	.004	3	4
LUNG_SCLC	PLOD3 →	+1.092	+1.042	.009	.002	3	3
LUNG_SCLC	HOXD11 →	-2.995	-1.103	<.001	.005	3	3
BLOOD_Myeloma	ZNF516 →	-1.938	-1.255	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PBX1 by Male sex differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →