Male sex differentiation

Across TCGA cell cohorts, RNA activity of the Male sex differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTF2, DEGS2, and MAP3K2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male sex differentiation activity versus TTF2 in SKIN (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TTF2 →	+0.928	+0.204	.003	.001	3	6
BREAST	DEGS2 →	-3.171	-0.293	.001	<.001	3	5
BREAST	MAP3K2 →	+0.936	+0.262	.004	.005	3	5
LUNG_SCLC	NEPRO →	+0.571	+0.196	.005	.008	3	5
CNS	PPIP5K2 →	+0.549	+0.183	.001	.001	3	5
URINARY_TRACT	TRAK2 →	+0.793	+0.228	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046661 vs TTF2 — SKIN

Explore this scatter interactively →