Female sex differentiation

Across TCGA patient cohorts, RNA activity of the Female sex differentiation pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSGALNACT2, NID2, and HSPG2, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female sex differentiation activity versus CSGALNACT2 in ACC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	CSGALNACT2 →	+1.458	+0.033	<.001	<.001	3	32
THYM	NID2 →	+2.085	+0.031	<.001	<.001	3	32
TGCT	HSPG2 →	+2.059	+0.052	<.001	<.001	3	31
THYM	JMJD1C →	+1.371	+0.033	<.001	<.001	3	31
THYM	NFAT5 →	+2.045	+0.036	<.001	<.001	3	30
DLBC	RIC1 →	+1.544	+0.043	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046660 vs CSGALNACT2 — ACC

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