Female sex differentiation

Across TCGA patient cohorts, RNA activity of the Female sex differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINF1, TIMP2, and TPM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female sex differentiation activity versus SERPINF1 in PDAC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SERPINF1 →	+0.659	+0.037	<.001	<.001	3	7
OV	TIMP2 →	+0.569	+0.042	.003	<.001	3	7
BRCA	TPM2 →	+0.793	+0.028	<.001	<.001	3	7
OV	ACTN1 →	+0.337	+0.033	.004	.001	3	7
OV	CAVIN1 →	+0.741	+0.040	<.001	<.001	3	7
BRCA	CAVIN3 →	+0.597	+0.025	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046660 vs SERPINF1 — PDAC

Explore this scatter interactively →