Female sex differentiation

Across TCGA patient cohorts, RNA activity of the Female sex differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMX1, PI15, and TCEAL4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female sex differentiation activity versus EMX1 in LSCC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EMX1 →	+0.336	+0.568	.007	.002	3	3
LSCC	PI15 →	+0.817	+0.867	<.001	<.001	3	3
BRCA	TCEAL4 →	+0.522	+0.679	.003	<.001	3	3
BRCA	NXPH3 →	+0.719	+0.490	.003	<.001	3	3
HNSC	DPH6 →	+0.436	+0.406	.003	.006	3	3
LUAD	ZDHHC7 →	-0.362	-0.602	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046660 vs EMX1 — LSCC

Explore this scatter interactively →