Female sex differentiation

Across TCGA cell cohorts, RNA activity of the Female sex differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2L1, ACTR3, and EIF3J, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCL2L1 grouped by Female sex differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BCL2L1 →	-0.706	-0.147	<.001	.003	3	7
OVARY	ACTR3 →	+0.341	+0.239	<.001	<.001	3	6
OVARY	EIF3J →	+0.284	+0.142	<.001	.006	3	5
CNS	INHA →	-0.341	-0.211	<.001	.001	2	5
LIVER	COL11A2 →	-0.318	-0.219	.008	.003	3	4
URINARY_TRACT	BARD1 →	-0.191	-0.233	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCL2L1 by Female sex differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →