Female sex differentiation

Across TCGA cell cohorts, RNA activity of the Female sex differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BC21, SPCS2, and CDK9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2BC21 grouped by Female sex differentiation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	H2BC21 →	+1.767	+0.265	.001	.005	3	5
BLOOD_Leukemia	SPCS2 →	-0.538	-0.209	.005	.004	3	4
BLOOD_Leukemia	CDK9 →	-0.894	-0.241	.003	.005	3	3
LIVER	WDTC1 →	-0.897	-0.850	<.001	.009	3	3
STOMACH	ALG11 →	-0.731	-0.476	<.001	<.001	3	3
BLOOD_Leukemia	UBE2L6 →	-1.992	-0.272	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2BC21 by Female sex differentiation activity — OESOPHAGUS

Explore this box plot interactively →