Female sex differentiation

Across TCGA cell cohorts, RNA activity of the Female sex differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHM3, DMGDH, and CLGN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female sex differentiation activity versus PLEKHM3 in BLOOD_Myeloma (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PLEKHM3 →	+0.821	+0.223	.001	.004	3	4
BLOOD_Myeloma	DMGDH →	+1.400	+0.265	<.001	<.001	3	4
BLOOD_Leukemia	CLGN →	+1.837	+0.678	.004	.005	2	5
BLOOD_Myeloma	IFFO2 →	-1.911	-0.249	.001	.008	3	4
UPPER_AERODIGESTIVE_TRACT	LRP12 →	+1.156	+0.176	.002	.003	3	3
LUNG_SCLC	PAH →	+1.786	+0.252	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046660 vs PLEKHM3 — BLOOD_Myeloma

Explore this scatter interactively →