Folic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Folic acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHMT1, LUZP1, and TTC27, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid metabolic process activity versus SHMT1 in LSCC (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SHMT1 →	+0.288	+0.038	.003	.001	3	6
LUAD	LUZP1 →	-0.160	-0.032	.006	.005	3	5
BRCA	TTC27 →	+0.228	+0.024	.002	.006	2	6
OV	SEPTIN8 →	-0.351	-0.045	.001	.001	2	5
LUAD	TP53 →	+0.697	+0.034	.001	.007	3	4
UCEC	EIF2B1 →	+0.144	+0.041	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046655 vs SHMT1 — LSCC

Explore this scatter interactively →