Folic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Folic acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TK1_S231, TNKS1BP1_S494, and IRF2BP2_S460, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid metabolic process activity versus TK1_S231 in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TK1_S231 →	+0.873	+0.220	<.001	<.001	3	3
GBM	TNKS1BP1_S494 →	-0.624	-0.251	<.001	<.001	3	3
LSCC	IRF2BP2_S460 →	+0.694	+0.287	<.001	.001	3	3
BRCA	PUS1_S420 →	+0.518	+0.236	<.001	<.001	3	3
OV	CDK17_S165 →	+0.365	+0.161	<.001	<.001	3	3
GBM	BRF1_S358 →	-0.932	-0.230	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046655 vs TK1_S231 — OV

Explore this scatter interactively →