Tetrahydrofolate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Tetrahydrofolate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GART, ZNF724, and MIS18BP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrofolate biosynthetic process activity versus GART in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GART →	+0.422	+0.079	<.001	.003	3	4
OV	ZNF724 →	+0.453	+0.125	.003	.002	3	4
OV	MIS18BP1 →	+0.337	+0.093	.008	<.001	3	4
OV	RFC3 →	+0.691	+0.151	<.001	<.001	3	4
OV	CENPU →	+0.739	+0.124	.002	<.001	3	4
BRCA	ELAVL2 →	+0.810	+0.075	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046654 vs GART — BRCA

Explore this scatter interactively →