Tetrahydrofolate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Tetrahydrofolate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGCE, SDK1, and JPH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SGCE grouped by Tetrahydrofolate biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SGCE →	-1.776	-0.806	.002	.002	3	4
LARGE_INTESTINE	SDK1 →	-1.240	-1.107	.002	<.001	3	4
LARGE_INTESTINE	JPH2 →	-1.404	-1.024	.002	.001	3	4
LARGE_INTESTINE	CAVIN1 →	-1.909	-0.836	.004	.007	3	4
SKIN	RNF144B →	+1.710	+0.990	.001	.002	3	4
SKIN	TLE2 →	-1.437	-1.280	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SGCE by Tetrahydrofolate biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →