Tetrahydrofolate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Tetrahydrofolate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MTHFD1L, XRCC5, and RPL5, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrofolate biosynthetic process activity versus MTHFD1L in SOFT_TISSUE (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MTHFD1L →	+1.566	+0.277	<.001	.001	3	17
URINARY_TRACT	XRCC5 →	+0.999	+0.627	<.001	<.001	3	10
URINARY_TRACT	RPL5 →	+1.378	+0.586	<.001	<.001	3	9
PANCREAS	BUB3 →	+0.956	+0.300	.001	.001	3	9
URINARY_TRACT	TCP1 →	+2.522	+0.598	<.001	<.001	3	8
URINARY_TRACT	EIF2S1 →	+2.553	+0.617	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046654 vs MTHFD1L — SOFT_TISSUE

Explore this scatter interactively →