Tetrahydrofolate metabolic process

Across TCGA patient cohorts, RNA activity of the Tetrahydrofolate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHST1, LGALS2, and GZMB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrofolate metabolic process activity versus CHST1 in BRCA (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHST1 →	-0.814	-0.106	.002	.008	3	5
LSCC	LGALS2 →	+0.396	+0.133	.005	.004	3	4
BRCA	GZMB →	+1.271	+0.183	<.001	<.001	3	4
LSCC	FGFBP2 →	-1.650	-0.196	.004	<.001	3	4
LSCC	TIGIT →	+0.611	+0.245	.001	<.001	3	4
HNSC	TRBV19 →	+0.666	+0.178	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046653 vs CHST1 — BRCA

Explore this scatter interactively →