Tetrahydrofolate metabolic process

Across TCGA cell cohorts, RNA activity of the Tetrahydrofolate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC1, IL22RA1, and RILPL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHDC1 grouped by Tetrahydrofolate metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KLHDC1 →	-0.602	-1.145	<.001	<.001	3	5
STOMACH	IL22RA1 →	+2.500	+1.544	<.001	<.001	3	5
LARGE_INTESTINE	RILPL1 →	-1.233	-1.025	<.001	.003	3	5
LARGE_INTESTINE	DBI →	+0.774	+1.240	.004	.006	3	5
STOMACH	NR4A1 →	+2.357	+1.270	.006	.006	2	5
UPPER_AERODIGESTIVE_TRACT	BTG2 →	+1.371	+1.546	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHDC1 by Tetrahydrofolate metabolic process activity — SKIN

Explore this box plot interactively →