Tetrahydrofolate metabolic process

Across TCGA cell cohorts, RNA activity of the Tetrahydrofolate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCD4, TCF20, and XRCC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrofolate metabolic process activity versus ABCD4 in KIDNEY (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ABCD4 →	+0.888	+0.253	.005	.001	3	5
BLOOD_Leukemia	TCF20 →	+0.932	+0.220	<.001	<.001	3	5
URINARY_TRACT	XRCC5 →	+0.627	+0.347	.002	.003	3	5
UPPER_AERODIGESTIVE_TRACT	BANF1 →	+1.148	+0.276	.001	.004	3	5
BREAST	XRCC3 →	+0.657	+0.142	<.001	.002	3	5
BLOOD_Leukemia	CEP57 →	+0.944	+0.169	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046653 vs ABCD4 — KIDNEY

Explore this scatter interactively →