Positive regulation of gamma-delta T cell activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of gamma-delta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POU2F2, SCIMP, and DDAH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gamma-delta T cell activation activity versus POU2F2 in LSCC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POU2F2 →	+0.481	+0.444	<.001	.004	3	5
LSCC	SCIMP →	+0.546	+0.782	.001	<.001	3	5
LUAD	DDAH1 →	-0.603	-0.230	<.001	.008	3	4
LSCC	NCF1B →	+0.610	+0.642	<.001	.002	3	4
CCRCC	GMIP →	+0.368	+0.451	<.001	.006	3	4
LSCC	NCF1C →	+0.589	+0.612	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046645 vs POU2F2 — LSCC

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