Positive regulation of gamma-delta T cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of gamma-delta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX4, SOX13, and MARCKSL1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gamma-delta T cell activation activity versus SOX4 in BLOOD_Leukemia (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SOX4 →	+2.977	+0.458	<.001	<.001	3	18
SOFT_TISSUE	SOX13 →	+1.721	+1.127	<.001	<.001	3	12
SOFT_TISSUE	MARCKSL1 →	+1.771	+1.085	<.001	<.001	3	10
BLOOD_Leukemia	CD24 →	+3.511	+0.260	<.001	<.001	3	9
URINARY_TRACT	PCOLCE2 →	-2.636	-0.344	<.001	.004	3	9
URINARY_TRACT	PIK3C2B →	+1.542	+0.330	<.001	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046645 vs SOX4 — BLOOD_Leukemia

Explore this scatter interactively →