Positive regulation of gamma-delta T cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of gamma-delta T cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMGB3, ARL6IP5, and RNASEH2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gamma-delta T cell activation activity versus HMGB3 in LUNG_NSCLC_LUSC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	HMGB3 →	+1.905	+1.586	.007	.009	3	5
BLOOD_Leukemia	ARL6IP5 →	-0.500	-0.225	.009	.002	3	5
BLOOD_Lymphoma	RNASEH2A →	+1.200	+0.272	<.001	<.001	3	4
BLOOD_Leukemia	NUDCD1 →	-0.791	-0.306	<.001	<.001	3	4
BLOOD_Leukemia	COLGALT1 →	-1.351	-0.308	<.001	<.001	3	4
BLOOD_Leukemia	ANP32B →	+0.487	+0.294	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046645 vs HMGB3 — LUNG_NSCLC_LUSC

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