Regulation of gamma-delta T cell activation

Across TCGA patient cohorts, RNA activity of the Regulation of gamma-delta T cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK11, FERMT3, and WDFY4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gamma-delta T cell activation activity versus DOCK11 in UCEC (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOCK11 →	+0.324	+0.074	<.001	<.001	3	10
GBM	FERMT3 →	+0.531	+0.082	<.001	<.001	3	10
GBM	WDFY4 →	+0.439	+0.088	<.001	<.001	3	9
BRCA	WIPF1 →	+0.470	+0.057	<.001	<.001	3	9
LSCC	DOCK10_S1257 →	+0.964	+0.076	<.001	<.001	3	9
GBM	DOCK2 →	+0.681	+0.106	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046643 vs DOCK11 — UCEC

Explore this scatter interactively →