Regulation of gamma-delta T cell activation

Across TCGA patient cohorts, RNA activity of the Regulation of gamma-delta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAMR1, LILRB1, and RUNX3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gamma-delta T cell activation activity versus PAMR1 in CCRCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PAMR1 →	-0.764	-0.700	<.001	<.001	3	4
HNSC	LILRB1 →	+0.730	+0.659	.001	.003	2	5
LSCC	RUNX3 →	+0.344	+0.425	.007	.009	2	5
CCRCC	CXCR2P1 →	+1.080	+0.611	.001	.003	3	4
HNSC	MAP4K1 →	+0.608	+0.529	<.001	.003	3	4
HNSC	ADORA2A-AS1 →	+0.296	+0.653	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046643 vs PAMR1 — CCRCC

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