Regulation of gamma-delta T cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of gamma-delta T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5orf60, POLR2B, and CLUL1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gamma-delta T cell activation activity versus C5orf60 in BLOOD_Leukemia (Pearson r = 0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C5orf60 →	+0.263	+1.657	.005	<.001	3	1
BLOOD_Leukemia	POLR2B →	+0.523	+1.677	.004	<.001	3	1
BLOOD_Leukemia	CLUL1 →	+0.643	+1.831	.001	<.001	3	1
BLOOD_Leukemia	IL32 →	-7.193	-1.608	<.001	.001	3	1
BLOOD_Leukemia	IL4 →	+4.766	+1.563	<.001	<.001	3	1
BLOOD_Leukemia	EIF2B2 →	+0.500	+1.475	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046643 vs C5orf60 — BLOOD_Leukemia

Explore this scatter interactively →