Negative regulation of alpha-beta T cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of alpha-beta T cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP4, EVI2B, and TRIM22, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of alpha-beta T cell proliferation activity versus GBP4 in HNSC (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GBP4 →	+0.740	+0.064	<.001	<.001	3	9
GBM	EVI2B →	+0.572	+0.077	<.001	<.001	3	9
LSCC	TRIM22 →	+0.455	+0.068	<.001	.001	3	8
GBM	PARVG →	+0.610	+0.086	<.001	<.001	3	8
GBM	SASH3 →	+0.517	+0.086	<.001	<.001	3	8
GBM	VAV1 →	+0.604	+0.095	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046642 vs GBP4 — HNSC

Explore this scatter interactively →