Negative regulation of alpha-beta T cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of alpha-beta T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYN, UBE2L6, and CSF2RB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of alpha-beta T cell proliferation activity versus LYN in HNSC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LYN →	+0.593	+0.496	<.001	.001	3	7
HNSC	UBE2L6 →	+1.002	+0.437	<.001	.005	3	7
LSCC	CSF2RB →	+1.065	+0.949	<.001	<.001	3	6
LSCC	TAP1 →	+0.921	+0.991	<.001	<.001	3	6
HNSC	CXCL10 →	+1.754	+0.565	<.001	<.001	3	6
HNSC	APOL6 →	+0.902	+0.654	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046642 vs LYN — HNSC

Explore this scatter interactively →