Negative regulation of alpha-beta T cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of alpha-beta T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LENG9, PELI3, and SMAD6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LENG9 grouped by Negative regulation of alpha-beta T cell proliferation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LENG9 →	+1.511	+1.427	.003	.009	3	4
BLOOD_Lymphoma	PELI3 →	+0.972	+1.555	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SMAD6 →	+1.144	+0.898	.003	<.001	3	4
LUNG_NSCLC_LUAD	NAXE →	+0.651	+0.605	<.001	.002	3	4
STOMACH	STAU1 →	-0.941	-1.220	<.001	.001	3	3
PANCREAS	RABIF →	+0.753	+1.372	.001	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LENG9 by Negative regulation of alpha-beta T cell proliferation activity — SOFT_TISSUE

Explore this box plot interactively →