Negative regulation of alpha-beta T cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of alpha-beta T cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TARBP2, ENC1, and COL6A6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TARBP2 grouped by Negative regulation of alpha-beta T cell proliferation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TARBP2 →	-0.165	-0.197	.003	.006	3	5
LUNG_NSCLC_LUSC	ENC1 →	-0.333	-0.221	<.001	.003	3	4
CNS	COL6A6 →	+0.302	+0.167	<.001	.001	3	4
SOFT_TISSUE	MSH5-SAPCD1 →	-0.209	-0.180	.003	.003	3	4
SKIN	OR2K2 →	+0.188	+0.140	.001	.002	3	4
BREAST	SLC16A13 →	+0.162	+0.142	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TARBP2 by Negative regulation of alpha-beta T cell proliferation activity — SOFT_TISSUE

Explore this box plot interactively →