Negative regulation of alpha-beta T cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of alpha-beta T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF14, CEACAM1, and BBC3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of alpha-beta T cell proliferation activity versus TNFRSF14 in STOMACH (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TNFRSF14 →	+3.028	+0.181	<.001	<.001	3	9
SKIN	CEACAM1 →	+1.728	+0.108	<.001	<.001	3	7
OESOPHAGUS	BBC3 →	+1.855	+0.203	<.001	<.001	3	7
BLOOD_Lymphoma	BCL11A →	-2.012	-0.107	.002	<.001	3	7
BLOOD_Lymphoma	CSE1L →	-0.779	-0.137	.002	.001	3	7
BLOOD_Lymphoma	ITGB3BP →	-0.604	-0.113	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046642 vs TNFRSF14 — STOMACH

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