Negative regulation of alpha-beta T cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of alpha-beta T cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCD, PDE1B, and KCNC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCD grouped by Negative regulation of alpha-beta T cell proliferation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PRKCD →	-0.133	-1.713	.005	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PDE1B →	+0.186	+2.174	.007	.002	3	4
URINARY_TRACT	KCNC4 →	-0.185	-1.592	<.001	<.001	2	4
URINARY_TRACT	PDE4DIP →	+0.275	+1.592	<.001	<.001	3	3
PANCREAS	PLCB2 →	-0.184	-0.616	.007	.005	3	3
BREAST	SAT2 →	+0.137	+1.346	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCD by Negative regulation of alpha-beta T cell proliferation activity — KIDNEY

Explore this box plot interactively →