Negative regulation of alpha-beta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of alpha-beta T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCN3, C1S, and CTHRC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of alpha-beta T cell differentiation activity versus RCN3 in LSCC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCN3 →	+0.650	+0.054	<.001	<.001	3	7
OV	C1S →	+0.485	+0.032	.002	.008	3	7
OV	CTHRC1 →	+0.934	+0.042	.002	<.001	2	8
GBM	SULF1 →	+1.343	+0.084	<.001	<.001	3	7
LSCC	ELMO2 →	+0.308	+0.051	<.001	<.001	3	7
LUAD	PPP1R18_S224 →	+0.537	+0.049	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046639 vs RCN3 — LSCC

Explore this scatter interactively →