Negative regulation of alpha-beta T cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of alpha-beta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, ANXA1, and VIM, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of alpha-beta T cell differentiation activity versus LGALS1 in BREAST (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LGALS1 →	+3.734	+0.579	<.001	<.001	3	10
LIVER	ANXA1 →	+5.107	+0.288	.007	<.001	3	8
LUNG_NSCLC_LUSC	VIM →	+5.486	+0.427	.002	.004	3	8
LUNG_SCLC	MTARC1 →	-1.080	-0.236	.009	.002	3	8
OVARY	EHD2 →	+3.112	+0.364	.001	.001	3	8
LIVER	TRIM7 →	+2.683	+0.277	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046639 vs LGALS1 — BREAST

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