Positive regulation of alpha-beta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of alpha-beta T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and RNASE6, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of alpha-beta T cell differentiation activity versus RCSD1 in UCEC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCSD1 →	+0.731	+0.062	<.001	<.001	3	10
LSCC	RCSD1_S351 →	+0.602	+0.059	<.001	<.001	3	10
OV	RNASE6 →	+0.687	+0.037	<.001	.007	3	10
HNSC	SAMSN1_S107 →	+0.821	+0.077	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.851	+0.065	<.001	<.001	3	10
HNSC	SASH3 →	+0.661	+0.080	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046638 vs RCSD1 — UCEC

Explore this scatter interactively →