Positive regulation of alpha-beta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of alpha-beta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SASH3, NCKAP1L, and ARHGAP15, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of alpha-beta T cell differentiation activity versus SASH3 in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SASH3 →	+0.906	+0.479	<.001	<.001	3	9
HNSC	NCKAP1L →	+0.872	+0.356	<.001	.001	3	9
UCEC	ARHGAP15 →	+0.871	+0.776	<.001	.001	3	9
LSCC	CORO1A →	+0.862	+0.366	<.001	<.001	3	8
LSCC	RASAL3 →	+0.818	+0.399	<.001	<.001	3	8
HNSC	BTK →	+0.822	+0.315	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046638 vs SASH3 — LSCC

Explore this scatter interactively →