Positive regulation of alpha-beta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of alpha-beta T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AIF1, DEF6, and LCP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of alpha-beta T cell differentiation activity versus AIF1 in HNSC (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AIF1 →	+0.839	+0.535	<.001	<.001	3	8
GBM	DEF6 →	+0.599	+0.400	<.001	<.001	3	8
HNSC	LCP2 →	+0.791	+0.618	<.001	<.001	3	8
HNSC	ABI3 →	+0.640	+0.465	<.001	<.001	3	7
GBM	LPXN →	+0.615	+0.366	<.001	<.001	3	7
GBM	DOCK8 →	+0.499	+0.296	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046638 vs AIF1 — HNSC

Explore this scatter interactively →