Positive regulation of alpha-beta T cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of alpha-beta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTC, SBF1, and CAAP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BTC grouped by Positive regulation of alpha-beta T cell differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BTC →	-1.134	-0.845	.002	.004	3	3
LUNG_NSCLC_LUAD	SBF1 →	-0.727	-0.865	.002	.002	3	2
LUNG_NSCLC_LUAD	CAAP1 →	+0.544	+0.523	.002	.006	3	2
LUNG_NSCLC_LUAD	TRIM25 →	-0.663	-0.722	.001	.001	3	2
LUNG_NSCLC_LUAD	MSI2 →	+0.894	+0.712	<.001	.006	3	2
LUNG_SCLC	HAVCR2 →	-0.164	-0.929	.008	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BTC by Positive regulation of alpha-beta T cell differentiation activity — LUNG_NSCLC_LUAD

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