Positive regulation of alpha-beta T cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of alpha-beta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, CLPP, and DCAKD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of alpha-beta T cell differentiation activity versus ANXA1 in BREAST (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA1 →	+2.986	+0.699	.007	.004	3	5
STOMACH	CLPP →	+0.897	+0.294	<.001	<.001	3	4
STOMACH	DCAKD →	+1.303	+0.317	.003	.001	3	4
BONE	LONP1 →	+1.228	+0.326	.007	.007	3	4
STOMACH	SLC27A5 →	+1.154	+0.313	.002	.001	2	5
URINARY_TRACT	ANKIB1 →	-0.933	-0.268	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046638 vs ANXA1 — BREAST

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